Project 2: Endocrine Disrupting Chemicals,
Diet and Gonadal Toxicity




The goal of this project is to use mouse models to determine the mechanisms by which BPA and phthalates, together with a high-fat diet, adversely affect the development and function of the male and female reproductive system. Specifically, studies within this project will test the hypothesis that BPA and phthalates cause oxidative stress in developing and adolescent gonads and lead to infertility and/or premature reproductive senescence. Furthermore, this project will investigate whether exposure to BPA and phthalates interact with a high-fat diet to adversely affect the reproductive system, and whether these outcomes are transgenerational and are associated with epigenetic modifications in the offspring.